AmberLite XAD 1180N

Summary

Product identification

AmberLite™ XAD™ 1180N Polymeric Adsorbent is a macroporous, adsorbent resin supplied as insoluble white beads. It is a non-ionic, hydrophobic, crosslinked polymer.

Applications

• Recovery and purification of antibiotics, water-soluble steroids, enzymes, and proteins
• Recovery of plant extracts
• Enzyme immobilization
• Separation of non-polar organic solutes from polar solvents
• Scavenger or pre-column

Typical Properties

Physical Properties

• Matrix: Macroporous, crosslinked DVB
• Type: Adsorbent
• Functional Group: None
• Physical Form: White, opaque, spherical beads
• Nitrogen BET Surface Area: ~500 m²/g
• Average Pore Diameter: ~400 Å
• Total Pore Volume: ~1.4 mL/mL
• Water Retention Capacity: 61 – 67%

Particle Size

• Particle Diameter: 350 – 600 µm
• < 250 µm: ≤ 5.0%
• > 850 µm: ≤ 10.0%

Swelling (in solvent)

• Methanol: 10%
• 2-Propanol: 15%
• Acetone: 10%
• p-Xylene (via methanol): 10%

Density

• Particle Density: 1.015 – 1.025 g/mL
• Shipping Weight: ~660 g/L

Suggested Operating Conditions

• Maximum Operating Temperature: 150°C (302°F)
• pH Range (Stable): 1 – 14
• Bed Depth, min.:
  • Capture: 750 mm (2.5 ft)
  • Chromatography: 1500 mm (4.9 ft)
• Flowrates:
  • Loading: 2 – 16 BV*/h (usually)
  • Elution/Desorption: 1 – 4 BV/h
  • Regeneration: 1 – 4 BV/h
  • Rinse: 1 – 8 BV/h

* 1 BV (Bed Volume) = 1 m³ solution per m³ resin or 7.5 gal per ft³ resin

Regenerants or Eluting Agents

• Water-miscible organic solvents (methanol, ethanol, isopropanol, acetone, etc.) for hydrophobic compounds
• Pure solvents for regenerating resin fouled by oils and antifoams
• Dilute bases (0.1 – 0.5% NaOH) for weakly acidic compounds
• Strong bases (2 – 4% NaOH) for regenerating resins fouled with proteins, peptides
• Dilute acids (0.1 – 0.5% HCl) for weakly basic compounds
• Dilute oxidizing agents (< 0.5%) such as peroxide to enhance the removal of protein fouling
• Buffer elution for pH-sensitive compounds
• Water when adsorption is from an ionic solution
• Hot nitrogen or steam for volatile materials

Hydraulic Characteristics

• Figures 4 and 5 in the original document show estimated bed expansion and pressure drop as a function of backwash flowrate, temperature, and service flowrate, respectively.
• Backwash Expansion: Figure 4 is for a temperature range of 10 – 60°C (50 – 140°F).
• Pressure Drop: Figure 5 is for a temperature range of 4.4 – 65.6°C (40 – 150°F).

Application Information

Pretreatment

AmberLite™ XAD™ 1180N is shipped water-wet with sodium chloride (NaCl) and sodium carbonate (Na₂CO₃). These salts must be washed off before use, typically with water at a linear flowrate of 5 – 10 m/h. For sensitive applications, residual monomeric or oligomeric compounds may need removal via a regeneration step. If an alcohol is used for regeneration, it must be displaced with water before the first loading cycle.

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Disclaimer: This extraction may miss figures, footnotes, or revisions. Contractual data must match the OEM PDF revision used on the project.

Official datasheet (PDF)

Lenntech datasheet mirror