AmberLite XAD 16HP

Summary

Product identification

• Product Name: AmberLite™ XAD™ 16HP N Polymeric Adsorbent
• Type: Macroporous, Adsorbent Resin
• Manufacturer: DuPont

Description

AmberLite™ XAD™ 16HP N is a macroporous, non-ionic, fully-hydrated, hydrophobic, styrenic resin. It is characterized by its porosity, controlled pore size distribution, and high surface area. This resin is prepared to meet high purity specifications and is intended for bioprocessing applications in the pharmaceutical and organic chemical industries. It exhibits excellent physical resistance and thermal stability, with low swelling between solvent and aqueous media, making it suitable for both column and batch operations. It is generally used for the adsorption of water-soluble organic substances and is particularly useful in the separation and purification of antibiotics, vitamins, steroids, amino acids, enzymes, and polypeptides.

Applications

• Biopharmaceutical processing separation and purification (antibiotics, vitamins, steroids, amino acids, enzymes, polypeptides, etc.)

Typical Properties

Physical Properties

• Matrix: Macroporous, crosslinked DVB
• Functional Group: None
• Physical Form: White, opaque, spherical beads
• Nitrogen BET Surface Area: ~800 m²/g
• Total Pore Volume: ~0.6 mL/mL

Chemical Properties

• Ionic Form as Shipped: Not applicable
• Total Exchange Capacity: Not applicable
• Water Retention Capacity: 62 – 70%

Particle Size

• Particle Diameter: 600 – 750 µm
• Fines (< 300 µm): ≤ 3.0%
• Oversized (> 1180 µm): ≤ 5.0%

Density

• Particle Density: 1.015 – 1.025 g/mL
• Shipping Weight: 675 g/L

Suggested Operating Conditions

• Maximum Operating Temperature: 150°C (302°F)

• Bed Depth, min.: 700 mm (2.3 ft)

• Flowrates:

  • Loading: 2 – 16 BV*/h (usually)
  • Elution/Desorption: 1 – 2 BV/h
  • Regeneration: 1 – 2 BV/h
  • Rinse: 2 – 16 BV/h

• 1 BV (Bed Volume) = 1 m³ solution per m³ resin or 7.5 gal per ft³ resin

Regenerants

• Water-miscible organic solvents (methanol, ethanol, isopropanol, acetone, etc.) for hydrophobic compounds
• Dilute bases (0.1 – 0.5% NaOH) for weakly acidic compounds
• Dilute acids (0.1 – 0.5% HCl) for weakly basic compounds
• Water when adsorption is from an ionic solution
• Hot water or steam for volatile materials

Hydraulic Characteristics

Backwashing AmberLite™ XAD™ 16HP N Polymeric Adsorbent with water at 15°C (59°F) at a linear velocity of 1 m/h will produce a bed expansion of 70%.

Conditioning and Limits of Use

AmberLite™ XAD™ 16HP N Polymeric Adsorbent is generally ready to use after a simple regeneration followed by a rinse with 20 bed volumes of potable water.

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Disclaimer This extraction may miss figures, footnotes, or revisions. Contractual data must match the OEM PDF revision used on the project.

Official datasheet (PDF)

Lenntech datasheet mirror