AmberLite XAD 18

Summary

Product identification

• Product Name: AmberLite™ XAD™ 18 Polymeric Adsorbent
• Description: Macroporous, non-ionic, highly crosslinked polystyrenic adsorbent resin.
• Form Supplied: White, opaque, spherical beads in fully hydrated, wetcake form, imbibed with sodium chloride (NaCl) and sodium carbonate (Na₂CO₃).

Applications

• Recovery and purification of antibiotics, natural products, amino acids, and proteins.
• Designed for biopharmaceutical molecule separation with high capacity and selectivity.

Typical Properties

Physical Properties

• Matrix: Macroporous, crosslinked DVB
• Type: Adsorbent
• Functional Group: None
• Physical Form: White, opaque, spherical beads
• Nitrogen BET Surface Area: ~700 m²/g
• Average Pore Diameter: ~150 Å
• Particle Size:
  • Particle Diameter: 425 ± 50 μm
  • Uniformity Coefficient: ≤ 1.7 %
  • Fines (< 212 µm): ≤ 2 %
• Swelling (in solvent):
  • Methanol: 15 – 20 %
  • 2-Propanol: 15 – 20 %
  • Acetone: 10 – 15 %
• Density:
  • Particle Density: 1.03 g/mL
  • Shipping Weight: 650 g/L

Chemical Properties

• Binding Capacity for Ceph C (1% breakthrough): ≥ 60 g/L

Suggested Operating Conditions

• Maximum Operating Temperature: 150°C (302°F)
• pH Range (Stable): 1 – 14
• Bed Depth (min, Industrial): 1200 mm (3.9 ft)
• Flowrates:
  • Loading: 0.50 – 2 BV*/h
  • Elution/Desorption: 0.50 – 2 BV/h
  • Regeneration: 0.50 – 2 BV/h
  • Rinse: 0.50 – 2 BV/h
  • *1 BV (Bed Volume) = 1 m³ solution per m³ resin or 7.5 gal per ft³ resin

Regenerants or Eluting Agents

• Water-miscible organic solvents (methanol, ethanol, isopropanol, acetone, etc.)
• Alkaline solutions (e.g., 1 N NaOH)
• Dilute acids (0.1 – 0.5% HCl)
• Dilute oxidizing agents (< 0.5%) such as peroxide
• Hot nitrogen or steam

Hydraulic Characteristics

• Figures showing estimated bed expansion (backwash) and pressure drop (service flowrate) as a function of flowrate are provided in the original document.

Pretreatment

1. Salt Wash: Wash the resin in the column with deionized water at 2 – 3 BV/h until salt levels are sufficiently low.
2. Solvent Equilibration:
   • Equilibrate with 8 BV of 100% organic solvent (acetonitrile, acetone, ethanol, propanol, or methanol) at a maximum flowrate of 2 BV/h.
   • Equilibrate with 5 BV of a 50% organic solvent/water solution at a maximum flowrate of 1 BV/h.

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Disclaimer This extraction may miss figures, footnotes, or revisions. Contractual data must match the OEM PDF revision used on the project.

Official datasheet (PDF)

Lenntech datasheet mirror