DuoLite AP143/1083

Summary

Product identification

• Product Name: DUOLITE™ AP143/1083 Resin
• Description: Pharmaceutical Grade Anion Exchange Resin (Cholestyramine Resin USP)
• Copolymer: Styrene-divinylbenzene
• Type: Strong base anion
• Functional Group: Quaternary amine
• Physical Form: White to buff-colored, fine powder

Chemical Properties

• Ionic Form as Shipped: Cl⁻
• Loss on drying: 12.0% maximum
• Identity (by IR spectrum): Identical to USP reference standard
• Heavy metals: 0.002% maximum
• pH of slurry: 4.0–6.0
• Residue on ignition: 0.1% maximum
• Dialyzable quaternary amine: 0.05%
• Chloride content: 13.0–17.0%
• Sodium glycocholate exchange capacity: 1.8–2.2 g/g
• Organic volatile impurities <467>: Meets requirements

Particle Size

• < 425 microns: 100% minimum
• < 150 microns: 85% minimum
• < 75 microns: 50% maximum

Applications

• Taste Masking
• Drug Stabilization
• Controlled Release
• Active Ingredient

Drug Loading and Release

Batch equilibration is the preferred method for loading drugs. Conventional columnar operations are not suitable due to the fine particle size. The realized drug loading will be less than the theoretical anion exchange capacity. Loading efficiency is influenced by drug selectivity, concentration, competing anions, molecular weight, and swelling. Multiple equilibration stages may be needed for maximum loading.

Drug release in vivo is governed by diffusion rate through the polymer, resin selectivity, and electrolyte concentration.

---

Disclaimer: This extraction may miss figures, footnotes, or revisions. Contractual data must match the OEM PDF revision used on the project.

Official datasheet (PDF)

Lenntech datasheet mirror