Datasheet summary
(Datasheet)
Engineering summary from PDF text extraction for (Datasheet). Verify every value with the OEM datasheet.
Summary
Product identification
- Product Name: Biomax Membranes
- Membrane Material: Composite polyethersulfone with void-free structure.
- Key Features: Modified to reduce non-specific protein binding; resistant to harsh chemical cleaning and/or sanitization; designed for high flux applications.
- Applications:
- Concentration, buffer exchange, and depyrogenation of protein solutions containing biomolecules such as albumin, IgG, IgM, monoclonal antibodies, hormones, and growth factors.
- Harvest, clarification, and concentration of vaccines.
- Product Usage: Biomax membranes are found in Pellicon® XL devices and Pellicon 2 Cassettes.
Operating limits
- pH Compatibility: Compatible with solutions having a pH between 1 and 14.
- Chemical Resistance:
- Superior resistance to harsh cleaning chemicals with no degradation of processing performance through multiple cleaning cycles.
- No appreciable change in air integrity or BSA retention after 100 hours in 600 ppm chlorine.
- Consistently better retention and integrity compared to competitive polyethersulfone UF membranes after 380 hours in 1 N NaOH at 50 °C.
- Caustic cleaning regimens have no effect on protein retention or membrane integrity.
- A rigorous cleaning regimen of caustic plus hypochlorite can restore normalized water permeability (NWP) to near initial values.
Feed water
- Protein Binding: Low to moderate relative protein binding.
- Protein Concentration: For use with protein solutions containing more than 0.1 mg/mL of protein.
Product water
- Retention: Void-free structure results in excellent retention and higher yields.
- Retention Profile: The Biomax 10 kDa membrane exhibits a sharper retention profile compared to conventional 10 kDa membranes, leading to improved protein retention.
Mechanical / hydraulic
The following parameters are provided for Biomax 10 compared to a Conventional Polyethersulfone (10 kDa) membrane:
| Parameter | Biomax 10 | Conventional Polyethersulfone (10 kDa) |
|---|---|---|
| Retention (%) | 99.95 | 99.9 |
| Flux (lmh) | 118.0 | 80.0 |
| Recirculation rate (lpm) | 4.0 | 6.0 |
| Pipe diameter (inches) | 1.5 | 2.5 |
| Hold-up volume (liters) | 8.4 | 20.8 |
| Yield improvement (%) | 2 – 3 | — |
Biomax Membrane Molecular Weight Cut-offs (NMWL)
- Biomax 5 (PBCC): 5 kDa NMWL, Typical Application: Growth factors, hormones
- Biomax 8 (PBFC): 8 kDa NMWL, Typical Application: Growth factors, hormones
- Biomax 10 (PBGC): 10 kDa NMWL, Typical Application: Albumin, hemoglobin
- Biomax 30 (PBTK): 30 kDa NMWL, Typical Application: Enzymes
- Biomax 50 (PBQK): 50 kDa NMWL, Typical Application: IgGs
- Biomax 100 (PBHK): 100 kDa NMWL, Typical Application: Small viruses, antigens
- Biomax 300 (PBMK): 300 kDa NMWL, Typical Application: IgMs, large viruses
- Biomax 500 (PBVK): 500 kDa NMWL, Typical Application: Large viruses, colloids, particulates
- Biomax 1000 (PBXK): 1000 kDa NMWL, Typical Application: Large viruses, cells, colloids, particulates
Disclaimer: This summary is based on extracted text and may not include all figures, footnotes, or the latest revisions from the original OEM PDF datasheet. For contractual data and complete specifications, always refer to the official OEM PDF revision used on the project.
Official datasheet (PDF)
Curated from selected public technical reference material for discovery and preliminary comparison. This summary is not a substitute for a current certified manufacturer datasheet. Verify revisions and design limits before use.